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In conclusion, we have systematically reviewed the literature regarding the influence of circadian and corticosterone variation on psychological responses. Our results suggest that distinct circulating cortisol concentrations at morning, noon, afternoon and evening on one day can potentially cause significant adverse effects on mood and social behavior during subsequent days. However, interpretation of many of the individual studies is difficult due to design and methodological inconsistencies across studies. There is evidence that the timing of the salivary cortisol sample and corticosterone dosage may influence HPA activation in older individuals. The optimal sample and dosage time point of these hormones and the duration of the stress intervention may need to be re-evaluated for older adults when designing cortisol-based interventions.
Might we design a methodology for these cortisol-based interventions to better target the potentially subtle differences in cortisol concentrations at noon or night that may modulate older adults’ psychological outcomes? To determine the best time of the day to promote psychological well-being in older adults would require a randomized, placebo-controlled investigation in older adults across the age span. Even as a first step, the timing of cortisol collection could be assessed in older adults to determine its potential impact on psychological responses. This would